I went through the hell of Paxill withdrawals and still don't feel like their gone totally.
Most importantly, how bad are the withdrawals if you stop taking the medication?
In what follows I’m relying heavily on two websites that try to keep up to date, John Grohol’s Psych Central and John Mc Manamy’s Mc Man’s Depression and Bipolar Web.
Mc Manamy, a bipolar survivor, deserves special credit for keeping his site running on donations and subscriptions, and avoiding Big Pharma advertising. Medications for depression fall into several major groups: MAOI inhibitors, tricyclics, SSRIs and SNRIs, and a few others that are hard to classify. In Europe, these were (pre-SSRI) usually considered the first line of treatment, preferred over tricyclics, while in the U. they are often resorted to only when everything else has failed.
I have little to say about how they work, because no one really knows much about that; the original explanation, that SSRIs work by stabilizing serotonin levels in the brain, seems doubtful now, but no one has come up with another explanation.
There are always new medications in the pipeline and new research findings about current medications, so it’s difficult to keep current.
I was on lexapro for a while but wasn't sure about it.
These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24; there was a reduction in risk with antidepressant use in patients aged 65 and older In patients of all ages who are started on antidepressant therapy, monitor closely for worsening, and for emergence of suicidal thoughts and behaviors. If a dose of Cymbalta is missed, take the missed dose as soon as it is remembered.
Advise families and caregivers of the need for close observation and communication with the prescriber Swallow Cymbalta whole. Do not open the capsule and sprinkle its contents on food or mix with liquids. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time.
Do not take two doses of Cymbalta at the same time.
In my limited experience, when MAOIs work they seem to make people a little hyper and obsessional—people will get an idea and follow it far beyond where others would have given up—but they are energized and do feel much better.
Until the advent of SSRIs, tricyclics were the standard treatment for depression.